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Diazepam is prescribed for various neuropsychiatric disorders: neuroses, psychopathies, as well as for neurotic and psychopathic conditions in schizophrenia, organic brain lesions, including cerebrovascular diseases, somatic diseases, accompanied by signs of emotional stress, anxiety, fear, increased irritability , sestestypochondritic, obsessive and phobic disorders, with sleep disorders. It is also used to arrest psychomotor agitation and anxiety agitation in these diseases. You can buy diazepam online UK without prescription in our online pharmacy.

Information

Interacts with specific benzodiazepine receptors located in the postsynaptic GABA-receptor complex in the limbic system of the brain, thalamus, hypothalamus, ascending activating reticular formation of the brainstem and intercalary neurons of the lateral horns of the spinal cord. Increases the sensitivity of GABA receptors to the mediator (GABA), which causes an increase in the opening frequency in the cytoplasmic membrane of the neurons of the channels for the incoming currents of chloride ions. As a result, the inhibitory effect of GABA and the inhibition of interneuronal transmission in the relevant sections of the central nervous system increase. Anxiolytic activity is manifested by the ability to stop internal anxiety, fear, anxiety, stress. Has antipanic and amnestic (mainly with parenteral application) action.

Indications

Conditions / diseases in which the use of Diazepam is recommended: Epileptic status; Sleep disturbance, motor arousal of various etiologies in psychiatry and neurology, abstinence syndrome due to chronic alcoholism; Neuroses, borderline states with elements of tension, anxiety, anxiety, fear; Spastic conditions associated with damage to the spinal cord or brain, as well as myositis, arthritis, bursitis with muscular tension; Tetanus.

Contraindications

Severe chronic hypercapnia; Severe myasthenia gravis; Alcohol or drug dependence in history (except for acute withdrawal); Hypersensitivity to the components of the drug, as well as other drugs of the benzodiazepine series. In the first trimester of pregnancy, the use of diazepam is contraindicated and allowed only in case of emergency. It is important to consider that the use of a tranquilizer during pregnancy can significantly change the heart rate (fetal heart rate) of the fetus.

Dosing and Administration

The tablet can be divided into two equal parts to facilitate dosing. Inside. To achieve maximum effect, dosage should be selected individually. The usual daily dosages given below meet the needs of most patients, however, some patients may require higher doses. In such cases, the dose should be increased cautiously, to avoid side effects. A single dose should not exceed 10 mg. The time of taking the drug depends on the individual characteristics of the patient. With multiple admission a large dose is recommended in the evening. Anxiety disorders and anxiety symptoms decrease: 2.5-10 mg 2-4 times a day.

Side effects

The most common side effects are fatigue, drowsiness and muscle weakness, which, as a rule, depend on the dose. These effects occur primarily at the beginning of treatment and usually disappear with further administration of Diazepam. From the nervous system: ataxia, dysarthria, slurred speech, headache, tremor, dizziness. Anterograde amnesia can occur in therapeutic doses, with the risk increasing with increasing doses. Amnesia can be accompanied by inadequate behavior.

Interactions

Potentiates the effects of alcohol, anticonvulsant and hypotensive drugs, neuroleptics, tricyclic antidepressants, analgesics (including narcotic analgesics), hypnotic drugs, general anesthetics, muscle relaxants, antihistamines with sedative effect. Analeptics, psychostimulants - reduce activity. Antacids can slow down, but not the degree of absorption of diazepam.

Special instructions

It should be borne in mind that anxiety or stress associated with everyday stress usually do not require treatment with anxiolytics. It is not allowed to mix diazepam with other drugs in one syringe (possibly settling the drug on the walls). When IV administration is introduced into large veins and slowly, controlling the function of breathing. It is necessary to avoid solution entering the artery and extravasal space.

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